Opportunity Information: Apply for RFA RM 16 018
This funding opportunity, titled "Limited Competition: NIH Health Care Systems Research Collaboratory - Coordinating Center (U24)" (RFA-RM-16-018), is a National Institutes of Health cooperative agreement designed to continue support for a single Coordinating Center that provides national leadership for the NIH Health Care Systems (HCS) Research Collaboratory. The program is focused on improving how research is planned, executed, and translated into real-world practice when it is conducted in direct partnership with health care delivery systems. Rather than funding multiple coordinating hubs, the announcement anticipates one award, positioning the selected center as the backbone infrastructure for the broader Collaboratory effort.
At its core, the Coordinating Center is expected to develop and refine the practical playbook for doing research inside operational health care environments. This includes further developing, adapting, and promoting the adoption of technical guidance, policy guidelines, and best practices that make studies feasible in real clinical settings. In pragmatic clinical research, studies must align with routine care workflows, data systems, compliance requirements, and patient protections, so the center is essentially responsible for creating and maintaining shared standards and solutions that health systems and investigators can rely on.
A major responsibility described in the announcement is hands-on collaboration with each Demonstration Project team funded through the Collaboratory. These Demonstration Projects are the individual research studies, and the Coordinating Center supports them by helping design, test, and implement their proposed work. The support is not limited to general advice; it specifically includes technical assistance, study design support, and coordination functions that help projects move from planning into execution across partnering health care systems. This is especially important for multi-site, system-embedded trials where alignment across institutions, consistent implementation, and shared problem-solving can determine whether a trial succeeds.
The opportunity also emphasizes learning and dissemination as central deliverables. The Coordinating Center is expected to identify what actually works when engaging health care systems as research partners, then spread those strategies to the field to improve health outcomes and care delivery. In practical terms, this means capturing lessons on partnership building, governance structures, data use agreements, stakeholder engagement, and integration of research procedures into clinical operations, then translating those lessons into guidance and resources other teams can use.
In addition, the Coordinating Center is tasked with advancing the broader science of pragmatic clinical trials conducted in health care systems. The goal is not only to support current Demonstration Projects, but also to strengthen the scientific community's ability to run future pragmatic trials more efficiently and effectively. That involves learning what trial methods are most feasible in real-world care settings, developing improved approaches, and disseminating those approaches widely so that future trials can be executed with fewer barriers, higher quality, and stronger relevance to everyday patient care.
Finally, the announcement makes it clear that the Coordinating Center functions as the central resource for the entire HCS Collaboratory. This implies a hub role: coordinating activities, serving as a shared source of expertise and tools, and helping ensure consistency and momentum across the program. Because the award mechanism is a cooperative agreement (U24), it also signals substantial NIH involvement during the project period, reflecting an expectation of ongoing collaboration between the awardee and NIH staff in guiding priorities, deliverables, and program coordination.
Key administrative details included in the source data are that the sponsoring agency is the U.S. Department of Health and Human Services through the National Institutes of Health, the activity category is Health, and the CFDA number is 93.310. Eligibility is limited to public and state-controlled institutions of higher education, and the competition is described as limited, meaning the applicant pool is restricted rather than broadly open. The opportunity was created on November 23, 2016, with an original closing date of February 2, 2017. The award ceiling is listed as $2,000,000, and the expected number of awards is one, reinforcing that this is intended to fund a single national coordinating entity rather than multiple centers.Apply for RFA RM 16 018
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: NIH Health Care Systems Research Collaboratory - Coordinating Center (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310.
- This funding opportunity was created on Nov 23, 2016.
- Applicants must submit their applications by Feb 02, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $2,000,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education.
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