Opportunity Information: Apply for RFA PS 22 004
This funding opportunity (RFA PS 22 004) from the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), supports a multi-site research project focused on understanding HIV and STD risk and prevention behaviors among a diverse, community-based sample of gay, bisexual, and other men who have sex with men (MSM) at a moment when HIV prevention is changing quickly. The central idea is to track how MSM make decisions about PrEP and other prevention strategies over time as new PrEP options and prevention messaging approaches continue to emerge, and to use what is learned to improve real-world PrEP implementation communication.
The project is designed as a longitudinal, multi-region study operating across three U.S. regions, with at least one site located in the U.S. South. The geographic emphasis is not just for representativeness; it is meant to align the research with areas that carry a high burden of HIV and are central to national prevention goals. The NOFO expects the three research sites to be located in priority jurisdictions identified by the federal Ending the HIV Epidemic in the United States (EHE) initiative, so that the study directly supports EHE targets, the National HIV/AIDS Strategy and National Strategic Plan goals, and related federal prevention planning efforts.
A major requirement is that enrolled MSM participants receive regular, structured biomedical screening and linkage support throughout the study. Specifically, participants should receive alternating quarterly testing: an HIV test one quarter followed by an STD test the next quarter, repeating in an ongoing cycle. Alongside testing, the study must provide referrals to prevention and treatment services based on participant needs or requests. This embeds the research in a prevention service context, ensuring the study both observes behavior and supports participants in accessing care, prevention tools, and follow-up.
Beyond measuring behaviors and outcomes, the NOFO emphasizes developing and testing brief prevention messages that can improve protective behaviors, especially around PrEP uptake, adherence, persistence, and broader sexual health practices. The messaging component is expected to be evaluated using both quantitative and qualitative methods, meaning applicants should plan to combine numerical outcome tracking (for example, changes in PrEP use patterns, testing uptake, or reported risk behavior) with deeper contextual work (for example, interviews or focus groups exploring why certain messages resonate, what barriers exist, and how community norms and lived experience shape prevention choices). The goal is not simply to produce educational materials, but to empirically test messaging approaches that can be deployed in practical settings to strengthen PrEP implementation and HIV/STD prevention.
Another hallmark of the opportunity is the requirement for rapid reporting after each wave of data collection. Rather than waiting until the end of the project to publish findings, awardees are expected to generate timely summaries that identify emerging community trends and translate them into implications for prevention messaging. In practice, this means the study should function as an ongoing feedback loop: collect data, quickly identify changes in behaviors or needs, and use that information to refine or inform messaging and prevention strategies in near real time.
In terms of funding structure, the CDC plans to make one award under a cooperative agreement mechanism. A cooperative agreement generally signals substantial programmatic involvement by the funding agency compared to a standard grant, so applicants should be prepared for active coordination with CDC on study implementation, deliverables, and reporting. The anticipated award is a single multisite cooperative agreement covering all three research sites, with an award ceiling of $1,475,000 and an expected number of awards of one. The funding activity category is Health (CFDA 93.084).
Eligibility is broad and includes many public and nonprofit entities that could plausibly manage a three-site research and prevention-linked testing project. Eligible applicants include state, county, and city governments; special district governments; independent school districts; public and state-controlled institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; and nonprofit organizations both with and without 501(c)(3) status (with some limitations regarding institutions of higher education depending on nonprofit status). The opportunity was created on October 22, 2021, with an original application deadline of February 1, 2022 (applications due by 5:00 pm ET).
Overall, the opportunity is aimed at producing actionable, time-sensitive evidence on how MSM navigate HIV and STD prevention in a shifting PrEP landscape, while simultaneously generating and validating brief, effective messaging that can improve prevention outcomes. It is explicitly aligned with national HIV prevention priorities, requires routine HIV/STD testing and referral pathways for participants, and is structured to produce rapid, practical insights that can inform implementation efforts in communities most impacted by HIV.Apply for RFA PS 22 004
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Understanding HIV/STD Risk and Enhancing PrEP Implementation Messaging in a Diverse Community-Based Sample of Gay, Bisexual, and Other Men Who Have Sex with Men in a Transformational Era" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.084.
- This funding opportunity was created on Oct 22, 2021.
- Applicants must submit their applications by Feb 01, 2022 Electronically submitted applications must be submitted no later than 500 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,475,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Others (see text field entitled Additional Information on Eligibility for clarification).
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