Opportunity Information: Apply for RFA AG 25 019
The National Institutes of Health, through the National Institute on Aging (NIA), is offering a discretionary grant opportunity titled "The Impact of Stressors on the Biological Mechanisms of Aging and Other Aging-Associated Outcomes in Experimental Model Systems" (Funding Opportunity Number RFA-AG-25-019). The core idea behind this program is that stress is a normal part of real life, but many experimental aging studies in model systems do not intentionally include well-defined stress exposures. That gap can make it harder to translate discoveries about the biology of aging (including work on interventions meant to slow aging) into insights that hold up in the messy, stress-filled conditions that humans and other organisms actually experience. This NOFO is meant to push the field toward aging studies that explicitly incorporate stressors during adulthood and then track how those stressors shape biological aging and downstream outcomes.
The research focus is on stressor exposures during the post-development period, meaning adulthood rather than early development. Applicants are expected to use clearly characterized stressors, which can include physical, social, and environmental stressors, and to specify the stressor duration, intensity, and timing. The initial goal is to determine whether adult exposure to these stressors produces measurable changes in one or more of the "hallmarks of aging" (a commonly used framework for core biological processes that drive aging). In other words, the program is not only asking whether stress is "bad" in a general sense; it is asking applicants to connect defined stress exposures to concrete, quantifiable aging mechanisms in experimental systems.
This is a phased award using the R61/R33 mechanism, and clinical trials are not allowed. The first phase (R61) is exploratory and milestone-driven, providing up to two years of support to establish feasibility and generate convincing early evidence. In this phase, teams should be able to show that their chosen stressor paradigm in adulthood can move the needle on measurable aging biology endpoints, particularly those aligned with the hallmarks of aging. The expectation is that applicants will propose clear go/no-go milestones so the NIA can evaluate whether the project is ready to progress.
If the R61 milestones are successfully met, the project may transition to the second phase (R33), which can provide up to three additional years of support. The R33 phase is intended to scale up and deepen the work by testing how the stressor(s) influence broader aging outcomes such as lifespan, healthspan, and resilience. It also encourages studying interactions between stress exposure and other influential variables, such as genotype, diet, and anti-aging or geroprotective interventions. In practical terms, this second phase is where applicants can move from mechanism-focused signals to more integrated outcomes, including whether stress changes how organisms respond to dietary patterns, genetic backgrounds, or interventions designed to slow aging processes.
The NOFO is intentionally broad about the kinds of experimental systems that can be used. Applicants may propose in vitro systems, standard laboratory animal models, or well-characterized animal populations that are wild, captive, free-ranging, or domesticated. The emphasis is less on a single favored model and more on thoughtful design, clear stressor characterization, and strong measurement strategies that link stress exposure in adulthood to aging biology and aging-associated outcomes.
Eligibility is also broad and includes many organization types: state, county, and local governments; special district governments; independent school districts; public and state-controlled and private institutions of higher education; federally recognized Native American tribal governments; tribal organizations (including those other than federally recognized governments); public housing authorities/Indian housing authorities; nonprofits (with or without 501(c)(3) status); for-profit organizations (other than small businesses); small businesses; and other entities. The announcement also explicitly calls out additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. (foreign) organizations. That breadth signals an interest in attracting diverse teams, settings, and model systems while keeping the science centered on biological aging mechanisms and experimentally defined stress exposures in adulthood.
Key administrative details provided include the NIH as the agency, the activity category of Health, and the CFDA number 93.866 (NIA-related). The original closing date listed is 2024-11-07, and awards are structured around the two-year R61 plus the potential three-year R33 continuation, contingent on NIA determination that R61 milestones were met, alignment with NIA priorities, and availability of funds. The listing does not provide an award ceiling or expected number of awards in the source data shown, which typically means applicants should rely on the full NOFO text and NIH budget guidance for practical budgeting expectations.
Overall, this opportunity is aimed at making experimental aging research more realistic and informative by embedding adulthood stress exposures directly into study designs, then tracing how those exposures alter recognized mechanisms of aging and ultimately shape lifespan, healthspan, and resilience. The program is structured to support projects that start with a tightly defined, milestone-based proof-of-concept stage and then expand into more comprehensive tests of outcomes and interactions once the initial evidence base is strong.Apply for RFA AG 25 019
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "The Impact of Stressors on the Biological Mechanisms of Aging and Other Aging-Associated Outcomes in Experimental Model Systems (R61/R33 Clinical Trial Not allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on 2024-08-27.
- Applicants must submit their applications by 2024-11-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Browse more opportunities from the same category: Health
Next opportunity: Clinical Characterization of Cancer Therapy-induced Adverse Sequelae and Mechanism-based Interventional Strategies (R01 Clinical Trial Optional)
Previous opportunity: PPHF 2016: Epidemiology and Laboratory Capacity Program for Infectious Diseases – Building and Strengthening Epidemiology, Laboratory and Health Information Systems Capacity in State and Local Health Departments – Financed in part by 2016 Prev
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA AG 25 019
Applicants also applied for:
Applicants who have applied for this opportunity (RFA AG 25 019) also looked into and applied for these:
| Funding Opportunity |
|---|
| Short Courses Promoting Cross-National Analyses Using Data from the International Health and Retirement Study (HRS) and Harmonized Cognitive Assessment Protocol (HCAP) (R25 Clinical Trial Not Allowed) Apply for RFA AG 25 025 Funding Number: RFA AG 25 025 Agency: National Institutes of Health Category: Health Funding Amount: $350,000 |
| HIV PREVENTION FOR PEOPLE WITH DISABILITIES Apply for PEPFARWDHFY2402 Funding Number: PEPFARWDHFY2402 Agency: U.S. Mission to Namibia Category: Health Funding Amount: $16,000 |
| Strategies for Eliminating HIV Proteins (R01 Clinical Trial Not Allowed) Apply for RFA AI 24 057 Funding Number: RFA AI 24 057 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Strategies for Eliminating HIV Proteins (R21 Clinical Trial Not Allowed) Apply for RFA AI 24 064 Funding Number: RFA AI 24 064 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Tribal Undergraduate to Graduate Research Training and Leadership Experiences (TURTLE) Program (UE5/T32) Apply for PAR 24 235 Funding Number: PAR 24 235 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Tribal Undergraduate to Graduate Research Training and Leadership Experiences (TURTLE) Program (UE5/T34) Apply for PAR 24 236 Funding Number: PAR 24 236 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Clinical and Translational Science Award (UM1 Clinical Trial Optional) Apply for PAR 24 272 Funding Number: PAR 24 272 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIA Advanced Postdoctoral Career Transition Awards to Promote Diversity in Translational Research for AD/ADRD (K99/R00 Clinical Trial Not Allowed) Apply for PAR 24 271 Funding Number: PAR 24 271 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Fiscal Year 2025 Health Center Controlled Network (HCCN) Cooperative Agreements Apply for HRSA 25 018 Funding Number: HRSA 25 018 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Partnership for National Maternal and Child Health (MCH) Leadership Apply for HRSA 25 028 Funding Number: HRSA 25 028 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Section 206 of the Consolidated Appropriations Act, 2024: State Planning Grants to Promote Continuity of Care for Medicaid and CHIP Beneficiaries Following Incarceration Apply for CMS 2T2 25 001 Funding Number: CMS 2T2 25 001 Agency: Centers for Medicare Medicaid Services Category: Health Funding Amount: $5,000,000 |
| USAID integrated Delivery of Tuberculosis Service (iDOTS) Activity Apply for 72062024RFA00007 Funding Number: 72062024RFA00007 Agency: Nigeria USAID-Abuja Category: Health Funding Amount: $45,000,000 |
| Community and Organizational Resilience and Empowerment to Reduce, manage, and mitigate the risk (of emerging and re-emerging) Infectious Diseases (CORE2RID) Apply for 72048624R00003 Funding Number: 72048624R00003 Agency: Thailand USAID-Bangkok Category: Health Funding Amount: Case Dependent |
| Consortium for Neuroscience AD/ADRD in Low- and Middle-Income Countries (U01 Clinical Trial Not Allowed) Apply for RFA AG 25 032 Funding Number: RFA AG 25 032 Agency: National Institutes of Health Category: Health Funding Amount: $400,000 |
| Small Research Grant Program for the Next Generation of Researchers in Low- and Middle-Income Countries (LMICs) for Aging and Alzheimers Disease (AD) and AD-Related Dementias (ADRD) Research (R03 Clinical Trial Not Allowed) Apply for RFA AG 25 031 Funding Number: RFA AG 25 031 Agency: National Institutes of Health Category: Health Funding Amount: $100,000 |
| State-based Healthcare Extension Cooperatives to Accelerate Implementation of Actionable Knowledge into Practice (U19) Apply for RFA HS 24 004 Funding Number: RFA HS 24 004 Agency: Agency for Health Care Research and Quality Category: Health Funding Amount: Case Dependent |
| Organs-on-a-Chip in Dental, Oral, and Craniofacial Research (DOC-OoCs) (R01 Clinical Trial Not Allowed) Apply for RFA DE 25 001 Funding Number: RFA DE 25 001 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| Organs-on-a-Chip in Dental, Oral, and Craniofacial Research (DOC-OoCs) (R21 Clinical Trial Not Allowed) Apply for RFA DE 25 002 Funding Number: RFA DE 25 002 Agency: National Institutes of Health Category: Health Funding Amount: $275,000 |
| RFI for SOPHI Apply for RFI 442 24 006 Funding Number: RFI 442 24 006 Agency: Cambodia USAID-Phnom Penh Category: Health Funding Amount: $35,000,000 |
| Emergency Department Substance Use Surveillance System Apply for EDS EDS 24 001 Funding Number: EDS EDS 24 001 Agency: Office of National Drug Control Policy Category: Health Funding Amount: $150,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA AG 25 019", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.