Opportunity Information: Apply for PA 18 729
Research on the Health of Transgender and Gender Nonconforming Populations (R01 Clinical Trial Optional) is a National Institutes of Health (NIH) discretionary grant opportunity (Funding Opportunity Number PA 18 729) that supports investigator-initiated research projects focused on the health of transgender and gender nonconforming (TGNC) people across the lifespan. The announcement is an institute and center (IC) reissue of an earlier FOA, updated specifically to align with NIH clinical trial policy requirements, and it uses the R01 mechanism, meaning it is intended for robust, multi-year research projects that can address significant questions with strong study designs. The "clinical trial optional" label indicates that applicants may propose either clinical trials or non-trial research, depending on what is scientifically appropriate for the aims, as long as the application follows NIH rules that apply when a study meets the definition of a clinical trial.
The FOA emphasizes research on TGNC populations of all ages, explicitly including youth and adults who may be questioning their gender identity, as well as individuals who are in the process of transitioning or who have already transitioned socially, legally, and/or medically. It defines the population broadly to include people whose gender identity differs from the sex listed on their original birth certificate and people whose gender expression differs substantially from what is traditionally associated with that sex. In practice, this framing supports research that reflects the diversity within TGNC communities rather than limiting studies to a single subgroup, transition pathway, or age bracket.
In terms of purpose and scope, the opportunity is designed to expand the evidence base on TGNC health, including understanding health outcomes, risk and protective factors, access to and quality of care, and the social and structural conditions that shape health. Because it is an R01, projects can be mechanistic, clinical, behavioral, social, epidemiological, health services focused, or otherwise multidisciplinary, as long as the central focus remains the health of TGNC people. The "clinical trial optional" feature also creates room for intervention research when justified, such as testing strategies to improve engagement in care, reduce health disparities, or improve health-related outcomes, while also supporting observational, cohort, and other non-interventional designs.
Eligibility is broad and intentionally inclusive, spanning many types of applicant organizations. Eligible applicants include state, county, city or township governments, special district governments, and independent school districts; public and state-controlled institutions of higher education and private institutions of higher education; federally recognized Native American tribal governments as well as tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (other than small businesses) and small businesses; and other entities. The FOA also explicitly calls out additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations). This breadth signals NIH interest in drawing proposals from academic centers, community organizations, and public sector partners that are positioned to reach TGNC populations and address real-world health questions.
From an administrative standpoint, the opportunity is listed under multiple CFDA numbers (93.113, 93.172, 93.173, 93.242, 93.273, 93.307, 93.313, 93.361, 93.393, 93.394, 93.395, 93.396, 93.399, 93.855, 93.865, 93.866), reflecting that multiple NIH institutes and centers may participate or have related program interests. The funding instrument is a grant, the activity category spans education, environment, health, income security, and social services, and the original closing date listed for this FOA was January 7, 2021. No award ceiling or expected number of awards is specified in the provided listing, which is common for NIH FOAs where budgets depend on project scope, institute-specific paylines, and program priorities.
Overall, this FOA is aimed at strengthening rigorous, policy-relevant and clinically meaningful research on TGNC health by supporting well-powered and well-designed R01 studies, including (but not requiring) clinical trials. It encourages applicants from a wide range of institution types, including community-based and minority-serving organizations, which can be especially important for conducting culturally grounded research, improving recruitment and retention, and ensuring findings translate into better health and healthcare for TGNC people.Apply for PA 18 729
- The National Institutes of Health in the education, environment, health, income security and social services sector is offering a public funding opportunity titled "Research on the Health of Transgender and Gender Nonconforming Populations (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.172, 93.173, 93.242, 93.273, 93.307, 93.313, 93.361, 93.393, 93.394, 93.395, 93.396, 93.399, 93.855, 93.865, 93.866.
- This funding opportunity was created on 2018-03-28.
- Applicants must submit their applications by 2021-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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